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phospho-PTPN7 (Ser246) Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8BUM3 |
| Other Accession | Q8BUM3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40351 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated Synthesised phosphopeptide derived from mouse PTPN7 around the phosphorylation site of Ser246 |
| Epitope Specificity | CR(p-S)VK |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 tyrosine-protein phosphatase domain. |
| SUBUNIT | Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. |
| Gene ID | 320139 |
|---|---|
| Other Names | BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI; C920001D21Rik; Lcptp; PTN7_HUMAN; PTPN7; Hematopoietic protein-tyrosine phosphatase (HEPTP); Protein-tyrosine phosphatase LC-PTP; 3.1.3.48; PTN7_MOUSE; PTN7_RAT; protein tyrosine phosphatase non-receptor type 7; PTPN7 (phospho-S246); p-PTPN7; phospho-PTPN7; PTPN7 (phospho-Ser246) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ptpn7 |
|---|---|
| Function | May play a role in the regulation of T and B-lymphocyte development and signal transduction. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=Oxidized form is preferentially associated with actin cytoskeleton |
| Tissue Location | Expressed in bone marrow-derived mast cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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