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KCNJ6 Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P48542 |
| Other Accession | P48542 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 48652 Da |
| Physical State | Lyophilized or Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse KCNJ6 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | PBS, Glycerol, BSA. |
| SIMILARITY | Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily. |
| SUBUNIT | Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015] |
| Gene ID | 16522 |
|---|---|
| Other Names | BIR1; GIRK-2; GIRK2; KATP-2; KATP2; KCNJ7; KIR3.2; KPLBS; hiGIRK2; weaver; wv; KCNJ6_HUMAN; KCNJ6; Inward rectifier K(+) channel Kir3.2; Potassium channel, inwardly rectifying subfamily J member 6; KCNJ6_MOUSE; W; KCNJ6_RAT; potassium inwardly rectifying channel subfamily J member 6; potassium inwardly-rectifying channel, subfamily J, member 6; G protein-activated inward rectifier potassium channel 2 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Kcnj6 |
|---|---|
| Synonyms | Girk2, Kcnj7, W |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (By similarity). Forms a functional channel in association with KCNJ3/GIRK1 (PubMed:10341034). |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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