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Slco1a1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9QXZ6 |
| Other Accession | Q9QXZ6 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74396 Da |
| Physical State | Liquid |
| Immunogen | Recombinant mouse Slco1a1 protein |
| Epitope Specificity | 108-158/670 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the organo anion transporter (TC 2.A.60) family. [SIMILARITY] Contains 1 Kazal-like domain. |
| SUBUNIT | Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface. |
| Post-translational modifications | Glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | mediates the transport of sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes |
| Gene ID | 28248 |
|---|---|
| Other Names | A530084B21; OATP-1; Oatp1; Oatp1a1; Slc21a1; Slc21a3; SO1A1_MOUSE; Slco1a1; Sodium-independent organic anion-transporting polypeptide 1 (OATP-1); Solute carrier family 21 member 1; SO1A1_RAT; Organic anion-transporting polypeptide 1 (OATP-1); Sodium-independent organic anion transporter 1; |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Slco1a1 {ECO:0000312|MGI:MGI:1351891} |
|---|---|
| Function | Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:10600646, PubMed:11267661). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (PubMed:10600646). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity). |
| Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:P46720}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46720} |
| Tissue Location | Highly expressed in liver, and at lower levels in kidney (PubMed:10600646, PubMed:11267661). Not detected in other tissues (PubMed:10600646). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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