癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRRC33 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8BMT4 |
| Other Accession | Q8BMT4 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77140 Da |
| Physical State | Liquid |
| Immunogen | Recombinant mouse LRRC33 protein |
| Epitope Specificity | 21-209/693 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 21 LRR (leucine-rich) repeats. |
| SUBUNIT | Interacts with CYBB/NOX2; the interaction is direct By similarity. Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | LRRC33 is a 692 amino acid protein that contains 17 LRR repeats. The gene encoding LRRC33 maps to chromosome 3, which encodes over 1,100 genes. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Marfan syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3. |
| Gene ID | 224109 |
|---|---|
| Other Names | ELLP3030; GARPL1; LRRC33; SENEBAC; UNQ3030; E430025L02Rik; Lrcc33; RGD1310771; LRC33_HUMAN; NRROS; Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species; LRC33_MOUSE; LRC33_RAT; Leucine-rich repeat-containing protein 33^; leucine rich repeat containing 33; glycoprotein A repetitions predominant like 1 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Nrros {ECO:0000303|PubMed:24739962, ECO:0000312|MGI:MGI:2445095} |
|---|---|
| Function | Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (PubMed:29909984). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF- beta-1 (PubMed:29909984). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF- beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF- beta-1 by LRRC33/NRROS (PubMed:29909984). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF- kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein |
| Tissue Location | Mainly expressed in cells of hematopoietic origin, such as in immune organs such as lymph nodes, thymus and spleen (PubMed:24739962, PubMed:29909984). Among leukocytes, expressed at higher level in myeloid cell such as macrophages, neutrophils and dendritic cells (PubMed:24739962). Highly expressed in central nervous system-resident macrophages, including microglia and perivascular macrophages (PubMed:28459434, PubMed:29909984) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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