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Synaptopodin Recombinant Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8CC35 |
| Other Accession | Q8CC35 |
| Host | Rabbit |
| Clonality | Recombinant |
| Calculated MW | 99552 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Synaptopodin |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the synaptopodin family. |
| SUBUNIT | Interacts with BAIAP1. Interacts with actin (By similarity). Interacts (via PPxY motifs) with WWC1 (via WW domains). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. May be essential for the formation of spine apparatuses in spines of telencephalic neurons, involved in synaptic plasticity. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes. |
| Other Names | SYNPO1; 9030217H17Rik; 9130229N11; 9330140I15Rik; SYNPO_HUMAN; SYNPO; KIAA1029; SYNPO_MOUSE; SYNPO_RAT; synaptopodin |
|---|---|
| Dilution | WB=1:500-1000,IHC-P=1:200-800,IHC-F=1:200-800,IF=1:200-800 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Synpo |
|---|---|
| Synonyms | Kiaa1029 |
| Function | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon Cell projection, dendritic spine. Postsynaptic density. Synapse Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8N3V7}. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (PubMed:9314539). |
| Tissue Location | Expressed in brain, namely in the olfactory bulb, cerebral cortex, striatum, and hippocampus, but not in the cerebellum Also expressed in the podocytes of kidney glomeruli. In the hippocampus, mainly expressed in the principal cell layer of the dentate gyrus and Ammon's horn. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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