癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAM115C Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | A6NFQ2 |
| Other Accession | A6NFQ2 |
| Reactivity | Human |
| Predicted | Rat, Mouse, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 100906 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FAM115C |
| Epitope Specificity | 591-690/919 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the FAM115 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | TCAF2 (TRPM8 Channel Associated Factor 2) is a Protein Coding gene. Diseases associated with TCAF2 include Retinitis Pigmentosa 11. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is TCAF2C. |
| Gene ID | 285966 |
|---|---|
| Other Names | FAM115C; FAM139A; GATD9; GATD9B; TCAF2_HUMAN; TCAF2; TRP channel-associated factor 2; TRPM8 channel associated factor 2; family with sequence similarity 139, member A; family with sequence similarity 115, member C; TRPM8 channel-associated factor 2 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TCAF2 (HGNC:26878) |
|---|---|
| Function | [Isoform 2]: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. |
| Cellular Location | [Isoform 2]: Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. |
| Tissue Location | Isoform 2 is expressed in the prostate and in cancerous prostate samples. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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