癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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PTGEs/Prostaglandin E Synthase Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O14684 |
| Other Accession | O14684 |
| Reactivity | Human |
| Predicted | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17102 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PTGEs |
| Epitope Specificity | 85-152/152 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the MAPEG family. |
| SUBUNIT | Homotrimer. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Prostaglandin E synthase catalyses conversion of COX derived PGH2 to PGE2. It is a member of the MAPEG family. It may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain during inflammatory responses. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. |
| Gene ID | 9536 |
|---|---|
| Other Names | MPGES-1; PGES; MGST-IV; MGST1-L1; MGST1L1; MPGES; PIG12; PP102; PP1294; TP53I12; 2410099E23Rik; D2Ertd369e; zgc:110052; PTGES_HUMAN; PTGES; Glutathione peroxidase PTGES; Glutathione transferase PTGES; Microsomal glutathione S-transferase 1-like 1 (MGST1-L1); Microsomal prostaglandin E synthase 1 (MPGES-1); p53-induced gene 12 protein; 5.3.99.3; MPGES1; PTGES_MOUSE; Microsomal prostaglandin E synthase 1; prostaglandin E synthase; microsomal glutathione S-transferase 1-like 1; tumor protein p53 inducible protein 12; p53-induced gene 12; microsomal prostaglandin E synthase-1; glutathione S-transferase 1-like 1; MGST1-like 1 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTGES |
|---|---|
| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:17519235, PubMed:18682561). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGE3, though PGH2 remains the preferred substrate (PubMed:17519235). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15- hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5- hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). |
| Cellular Location | Membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97119
