癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PSMD11 Recombinant Mouse mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O00231 |
| Other Accession | O00231 |
| Host | Mouse |
| Clonality | Recombinant |
| Calculated MW | 47464 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PSMD11 |
| Epitope Specificity | 250-350/422 |
| Isotype | IgG3/Kappa |
| Purity | affinity purified by Protein G |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the proteasome subunit S9 family. Contains 1 PCI domain. |
| Post-translational modifications | Phosphorylated by AMPK. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012] |
| Gene ID | 5717 |
|---|---|
| Other Names | Rpn6; S9; p44.5; 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik; psmd11; wu:fb55b06; zgc:56580; zgc:77763; PSD11_BOVIN; 26S proteasome regulatory subunit RPN6; PSD11_HUMAN; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5; PSD11_MOUSE; PSD11_RAT; proteasome 26S subunit, non-ATPase 11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; 26S proteasome regulatory subuni |
| Dilution | WB=1:500-2000,IF=1:50-200,ELISA=1:1000-5000,IHC-P=1:50-200,IHC-F=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PSMD11 |
|---|---|
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. |
| Cellular Location | Nucleus. Cytoplasm, cytosol |
| Tissue Location | Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97140
