癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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KLF2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9Y5W3 |
| Other Accession | Q9Y5W3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37420 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KLF2 |
| Epitope Specificity | 1-100/355 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 3 C2H2-type zinc fingers. |
| SUBUNIT | Interacts with WWP1. |
| Post-translational modifications | Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011] |
| Gene ID | 10365 |
|---|---|
| Other Names | LKLF; KLF2_HUMAN; KLF2; Lung krueppel-like factor; KLF2_MOUSE; KLF2_RAT; KLF transcription factor 2; Kruppel-like factor 2 (lung); Kruppel like factor 2; lung Kruppel-like factor |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KLF2 |
|---|---|
| Synonyms | LKLF |
| Function | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). |
| Cellular Location | Nucleus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97163
