癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ELMO2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96JJ3 |
| Other Accession | Q96JJ3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 82615 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ELMO2 |
| Epitope Specificity | 101-200/720 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 ELMO domain. Contains 1 PH domain. |
| SUBUNIT | Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10, and ced-12 and their mammalian homologs CRKII, DOCK1, RAC1 and ELMO mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases. |
| Gene ID | 63916 |
|---|---|
| Other Names | CED-12; CED12; Ced-12A; ELMO-2; VMPI; 1190002F24Rik; ELMO2_BOVIN; ELMO2; ELMO2_HUMAN; Protein ced-12 homolog A (hCed-12A); CED12A; KIAA1834; ELMO2_MOUSE; Protein ced-12 homolog A; engulfment and cell motility 2; engulfment and cell motility 2 (ced-12 homolog, C. elegans) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ELMO2 |
|---|---|
| Synonyms | CED12A, KIAA1834 |
| Function | Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs) (PubMed:11595183, PubMed:11703939, PubMed:20679435, PubMed:32651375, PubMed:27476657). Acts in association with DOCK1, DOCK2, DOCK4 and CRK (PubMed:11595183, PubMed:20679435, PubMed:32651375, PubMed:27476657). Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility (PubMed:11595183). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol. Membrane |
| Tissue Location | Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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