SULF1 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF
Primary Accession	Q8IWU6
Other Accession	Q8IWU6
Host	Rabbit
Clonality	Polyclonal
Calculated MW	101027 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human SULF1
Epitope Specificity	601-700/871
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Additional Information
Gene ID	23213
Other Names	SULF1_HUMAN; SULF1; hSulf-1; Arylsulfatase; N-acetylglucosamine-6-sulfatase; KIAA1077; sulfatase 1; Extracellular sulfatase Sulf-1; Extracellular sulfatase Sulf-2 secreted form; SULF-1
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	SULF1
Synonyms	KIAA1077
Function	Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563).
Cellular Location	Endoplasmic reticulum {ECO:0000250\|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250\|UniProtKB:Q8VI60}. Cell surface
Tissue Location	Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down- regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines