癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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NTAN1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96AB6 |
| Other Accession | Q96AB6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34677 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NTAN1 |
| Epitope Specificity | 111-210/310 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] |
| Gene ID | 123803 |
|---|---|
| Other Names | PNAA; PNAD; RGD1305160; NTAN1_HUMAN; NTAN1; Protein NH2-terminal asparagine amidohydrolase (PNAA); Protein NH2-terminal asparagine deamidase (PNAD | Protein N-terminal Asn amidase | Protein N-terminal asparagine amidase | Protein NTN-amidase); 3.5.1.121; NTAN1_MOUSE; Protein NH2-terminal asparagine deamidase (PNAD | Protein N-terminal Asn amidase | Protein NTN-amidase); NTAN1_PIG; N-terminal asparagine amidase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NTAN1 |
|---|---|
| Function | N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q28955}. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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