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OR5V1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UGF6 |
| Other Accession | Q9UGF6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36057 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human OR5V1 |
| Epitope Specificity | 221-321/321 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008] |
| Gene ID | 81696 |
|---|---|
| Other Names | 6M1-21; hs6M1-21; OR5V1_HUMAN; OR5V1; Olfactory receptor OR6-26; olfactory receptor family 5 subfamily V member 1; olfactory receptor, family 5, subfamily V, member 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OR5V1 (HGNC:13972) |
|---|---|
| Function | G protein-coupled receptor that acts both as an odorant receptor, and as a classical G protein-coupled receptor outside the olfactory epithelium (By similarity). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL/G(olf) or GNAS/G(s)) (By similarity). In olfactory epithelium, activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12- dienoate, a plant odorant isolated from E.fortunei Turcz, promotes coupling to GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (By similarity). Beyond its role in olfaction, also acts as a regulator of glucose metabolism (By similarity). In liver, activation by oxylipin 12(S)- hydroxyeicosapentaenoate (12(S)-HEPE), initiates a signaling that enhances hepatic fatty acid oxidation via PKA-dependent activation of the transcription factor ATF2, which promotes expression of carnitine palmitoyltransferase CPT1A (By similarity). Outside of the olfactory system, in tissues lacking GNAL/G(olf), couples to GNAS/G(s), promoting activation of adenylate cyclase activity and production of cAMP (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:A2RT31}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A2RT31} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP97227
