癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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EPB41L5 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9HCM4 |
| Other Accession | Q9HCM4 |
| Predicted | Rat, Human, Mouse, Rabbit, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 81856 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human EPB41L5 |
| Epitope Specificity | 51-150/733 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 FERM domain. |
| SUBUNIT | Interacts with MPP5, CRB2 and CRB3. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. EPB41L5 (erythrocyte membrane protein band 4.1 like 5), also known as BE37 or YMO1, is a 733 amino acid cytoplasmic protein that contains one FERM domain, which it uses to bind CRB1 (crumbs homolog 1). EPB41L5 is a homolog of zebrafish 'mosaic eyes' (moe), and is widely expressed but found at highest levels in ovary, kidney and brain, and is known to colocalize with β-catenin. EPB41L5 may participate in tight junction positioning during the establishment of epithelial cell polarity, and exists as four alternatively spliced isoforms that are encoded by a gene located on human chromosome 2q14.2. |
| Gene ID | 57669 |
|---|---|
| Other Names | BE37; LULU; LULU1; YMO1; YRT; E41L5_HUMAN; EPB41L5; Erythrocyte membrane protein band 4.1-like 5; KIAA1548; erythrocyte membrane protein band 4.1 like 5; yurt homolog (Drosophila) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EPB41L5 |
|---|---|
| Synonyms | KIAA1548 |
| Function | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BGS1}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q8BGS1}. Cell membrane {ECO:0000250|UniProtKB:Q8BGS1}; Peripheral membrane protein. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q5FVG2} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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