癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAT4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q6V0I7 |
| Other Accession | Q6V0I7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 542687 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CDHF14 |
| Epitope Specificity | 4351-4450/4981 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 34 cadherin domains. Contains 6 EGF-like domains. Contains 2 laminin G-like domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014] |
| Gene ID | 79633 |
|---|---|
| Other Names | CDHF14; CDHR11; FAT-J; FATJ; HKLLS2; NBLA00548; VMLDS2; FAT4_HUMAN; FAT4; hFat4; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT atypical cadherin 4; FAT tumor suppressor homolog 4 (Drosophila); cadherin-related family member 11 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FAT4 |
|---|---|
| Synonyms | CDHF14, FATJ |
| Function | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Note=In the kidney, localizes to primary cilia. |
| Tissue Location | Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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