癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EFCAB4B Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BSW2 |
| Other Accession | Q9BSW2 |
| Reactivity | Mouse |
| Predicted | Rat, Human, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 83193 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human EFCAB4B |
| Epitope Specificity | 201-300/1503 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the EFCAB4 family. Contains 2 EF-hand domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | EF-CAB4B is a 395 amino acid protein belonging to the EF-CAB4 family. Localizing to cytoplasm, EF-CAB4B contains two EF-hand domains and exists as two alternatively spliced isoforms. At low Ca2+ concentrations, EF-CAB4B acts as a calcium-sensor, facilitating the clustering of Orai1 and Stim1 at the junctional regions between plasma membrane and endoplasmic reticulum, leading to regulation of CRAC channel activation. The gene encoding EF-CAB4B maps to human chromosome 12p13.32. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. |
| Gene ID | 84766 |
|---|---|
| Other Names | EFCAB4B; RAB46; Gm1073; Gm462; EFC4B_HUMAN; CRACR2A; Calcium release-activated calcium channel regulator 2A (CRAC channel regulator 2A); Calcium release-activated channel regulator 2A; Ras-related protein Rab-46; EFC4B_MOUSE; calcium release activated channel regulator 2A; EF-hand calcium binding domain 4B; Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; CRAC regulator 2A |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRACR2A (HGNC:28657) |
|---|---|
| Function | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
| Cellular Location | [Isoform 1]: Cytoplasm |
| Tissue Location | [Isoform 1]: Expressed in the Jurkat T-cell line. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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