癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC26A3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P40879 |
| Other Accession | P40879 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84505 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SLC26A3 |
| Epitope Specificity | 101-200/764 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain. |
| SUBUNIT | nteracts with CFTR, SLC26A6 and SLC9A3R1 (By similarity). Interacts with PDZK1. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| DISEASE | Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] Orthologsmouse all |
| Gene ID | 1811 |
|---|---|
| Other Names | CLD; DRA; 9030623B18Rik; 9130013M11Rik; S26A3_HUMAN; SLC26A3; Down-regulated in adenoma (Protein DRA); Solute carrier family 26 member 3; S26A3_MOUSE; S26A3_RAT; congenital chloride diarrhea; solute carrier family 26, member 3; solute carrier family 26 (anion exchanger), member 3; down-regulated in adenoma; Chloride anion exchanger |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC26A3 |
|---|---|
| Synonyms | DRA |
| Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Membrane {ECO:0000250|UniProtKB:Q9WVC8}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localized in sperm membranes Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250|UniProtKB:Q9WVC8} |
| Tissue Location | Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP97274
