癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDE6C Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 4
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P51160 |
| Other Accession | Q91ZQ1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99147 Da |
| Antigen Region | 271-300 aa |
| Gene ID | 5146 |
|---|---|
| Other Names | Cone cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha', cGMP phosphodiesterase 6C, PDE6C, PDEA2 |
| Target/Specificity | This PDE6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human PDE6C. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE6C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE6C |
|---|---|
| Synonyms | PDEA2 |
| Function | As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PDE6C is the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa.
REFERENCES
Muradov, H., et al. J. Biol. Chem. 284(47):32662-32669(2009) Chang, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(46):19581-19586(2009) Thiadens, A.A., et al. Am. J. Hum. Genet. 85(2):240-247(2009)
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