癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
APBB3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O95704 |
| Other Accession | O95704 |
| Reactivity | Rat, Mouse |
| Predicted | Human, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52585 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human APBB3 |
| Epitope Specificity | 401-486/486 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 PID domains. Contains 1 WW domain. |
| SUBUNIT | Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. |
| Gene ID | 10307 |
|---|---|
| Other Names | FE65L2; SRA; Rirl2; TR2S; APBB3_HUMAN; APBB3; Protein Fe65-like 2 (Fe65L2); APBB3_MOUSE; APBB3_RAT; amyloid beta precursor protein binding family B member 3; amyloid beta (A4) precursor protein-binding, family B, member 3 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | APBB3 (HGNC:20708) |
|---|---|
| Function | May modulate the internalization of amyloid-beta precursor protein. |
| Cellular Location | Cytoplasm. Nucleus [Isoform I-245]: Nucleus. |
| Tissue Location | Expressed in various tissues, highest expression in brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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