癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BCL6B Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8N143 |
| Other Accession | Q8N143 |
| Predicted | Rat, Pig, Human, Mouse, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51531 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human BCL6B |
| Epitope Specificity | 141-440/479 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 BTB (POZ) domain.Contains 5 C2H2-type zinc fingers. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFⅹB expression, thereby inhibiting NFⅹB-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. |
| Gene ID | 255877 |
|---|---|
| Other Names | BAZF; ZBTB28; ZNF62; BCL6B_HUMAN; BCL6B; Bcl6-associated zinc finger protein; Zinc finger protein 62; BCL6B transcription repressor; B-cell CLL/lymphoma 6, member B (zinc finger protein); B-cell CLL/lymphoma 6, member B; B cell CLL/lymphoma 6B; BCL6B, transcription repressor |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BCL6B |
|---|---|
| Synonyms | BAZF, ZNF62 |
| Function | Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed with higher expression found in heart and placenta. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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