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ATF6 beta Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q5SSW7 |
| Other Accession | Q5SSW7 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ATF6 beta |
| Epitope Specificity | 301-400/703 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain. |
| SUBUNIT | Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). |
| Post-translational modifications | N-glycosylated. During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6beta homodimer or an ATF-6Alpha/beta heterodimer. Binding of the ATF-6beta homodimer or ATF-6Alpha/beta heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription. |
| Gene ID | 1388 |
|---|---|
| Other Names | ATF6beta; CREB-RP; CREBL1; G13; Q5SSW7_HUMAN; ATF6B_HUMAN; ATF6B; cAMP-dependent transcription factor ATF-6 beta; Activating transcription factor 6 beta (ATF6-beta); Protein G13; cAMP response element-binding protein-related protein (Creb-rp); cAMP-responsive element-binding protein-like 1; ATF6B_MOUSE; Q4G097_RAT; Q6MG80_RAT; activating transcription factor 6 beta; cAMP responsive element binding protein-like 1; Cyclic AMP-dependent transcription factor ATF-6 beta |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATF6 beta Rabbit pAb |
|---|---|
| Function | Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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