CACNB1 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF
Primary Accession	Q02641
Other Accession	Q02641
Host	Rabbit
Clonality	Polyclonal
Calculated MW	65714 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human CACNB1
Epitope Specificity	301-400/598
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain.
SUBUNIT	The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 (By similarity).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	The protein encoded by CACNB1 belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.

Additional Information
Gene ID	782
Other Names	CAB1; CACNLB1; CCHLB1; Cchb1; CACB1_BOVIN; CACNB1; Calcium channel voltage-dependent subunit beta 1; CACB1_HUMAN; CACB1_MOUSE; CACB1_RABIT; CACB1_RAT; calcium voltage-gated channel auxiliary subunit beta 1; calcium channel, voltage-dependent, beta 1 subunit
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	CACNB1
Synonyms	CACNLB1
Function	Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).
Cellular Location	Cell membrane, sarcolemma; Peripheral membrane protein {ECO:0000250\|UniProtKB:P19517}; Cytoplasmic side {ECO:0000250\|UniProtKB:P19517}. Cell membrane; Peripheral membrane protein
Tissue Location	Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.