癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM158 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WZ71 |
| Other Accession | Q8WZ71 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30404 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TMEM158 |
| Epitope Specificity | 188-260/300 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the TMEM158 family. |
| Post-translational modifications | N-glycosylated. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | TMEM158 is a 286 amino acid protein encoded by a gene mapping to human chromosome 3. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. |
| Gene ID | 25907 |
|---|---|
| Other Names | BBP; RIS1; p40BBP; 2310037P21Rik; TM158_BOVIN; TMEM158; Ras-induced senescence protein 1; TM158_HUMAN; 40 kDa BINP-binding protein (p40BBP); HBBP; TM158_MOUSE; Mbbp; TM158_RAT; Brain-specific binding protein; transmembrane protein 158; transmembrane protein 158 (gene/pseudogene); Ras induced senescence 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1 µg/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMEM158 |
|---|---|
| Synonyms | HBBP, RIS1 |
| Function | Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. |
| Cellular Location | Membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97399
