癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRLF3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8IUI8 |
| Other Accession | Q8IUI8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49766 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CRLF3 |
| Epitope Specificity | 21-120/442 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the cytokine receptor-like factor 3 family.Contains 1 fibronectin type-III domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012] |
| Gene ID | 51379 |
|---|---|
| Other Names | CREME-9; CREME9; CRLM9; CYTOR4; FRWS; p48.2; CRLF3_HUMAN; CRLF3; Cytokine receptor-like molecule 9 (CREME-9); Cytokine receptor-related protein 4; Type I cytokine receptor-like factor p48; P48; CRLF3_MOUSE; Cytokine receptor-related factor 4; cytokine receptor like factor 3; cytokine receptor-like factor 3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRLF3 |
|---|---|
| Synonyms | CREME9, CRLM9, CYTOR4, P48 |
| Function | May play a role in the negative regulation of cell cycle progression. |
| Cellular Location | Cytoplasm. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic |
| Tissue Location | Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97413
