癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NUT Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q86Y26 |
| Other Accession | Q86Y26 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 120314 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NUT |
| Epitope Specificity | 301-400/1160 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the FAM22 family. |
| Post-translational modifications | Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export. |
| DISEASE | Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein. Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | nuclear protein in testis is a 1,132 amino acid protein that is specifically expressed in testis. Belonging to the FAM22 family, NUT shuttles between nucleus and cytoplasm via a leptomycin-sensitive pathway. It is suggested that the translocation of the NUT gene is the cause of nuclear protein in testis midline carcinomas (NMC). NMCs are highly aggressive carcinomas typically arising in midline structures in young individuals. These carcinomas are characterized by the presence of a chromosomal rearrangement of the NUT gene on chromosome 15 (15q14), which results in a chromosomal translocation most commonly involving the BRD4 gene on chromosome 19p13. Endogenous BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation. |
| Gene ID | 256646 |
|---|---|
| Other Names | C15orf55; FAM22H; NUT; NUTM1_HUMAN; NUTM1; Nuclear protein in testis; NUT midline carcinoma family member 1; chromosome 15 open reading frame 55 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NUTM1 (HGNC:29919) |
|---|---|
| Synonyms | C15orf55, NUT |
| Function | Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. |
| Cellular Location | Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. |
| Tissue Location | Specifically expressed in testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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