癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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SRXN1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BYN0 |
| Other Accession | Q9BYN0 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 14259 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SRXN1 |
| Epitope Specificity | 45-137/137 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the sulfiredoxin family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Sulfiredoxin, also designated Sulfiredoxin-1 and chromosome 20 open reading frame 139 (C20orf139), is a cytoplasmic antioxidant protein involved in signaling through catalytic reduction of oxidative modifications. It regulates peroxiredoxins (PRXs), a family of proteins that reduce hydroperoxides, by reducing the conserved cysteine from sulfinic to sulfenic acid. This impacts the role of PRX in the reduction of other downstream transcription factors and kinase signaling pathways. The Sulfiredoxin protein specifically acts on the PRDX1, PRDX2, PRDX3 and PRDX4 peroxiredoxins, but not on PRDX5 or PRDX6. Sulfiredoxin acts as a phosphotransferase and an athioltransferase and is widely expressed, with highest levels detected in lung, spleen, kidney and thymus tissues. |
| Gene ID | 140809 |
|---|---|
| Other Names | C20orf139; Npn3; SRX; SRX1; 1700127B04Rik; TX01; Ab2-390; SRXN1_HUMAN; SRXN1; 1.8.98.2; SRXN1_MOUSE; Neoplastic progression protein 3; sulfiredoxin 1; chromosome 20 open reading frame 139; sulfiredoxin 1 homolog (S. cerevisiae); sulphiredoxin |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SRXN1 |
|---|---|
| Synonyms | C20orf139, SRX, SRX1 |
| Function | Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Widely expressed with highest levels in kidney, lung, spleen and thymus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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