癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GABARAPL3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9BY60 |
| Other Accession | Q9BY60 |
| Predicted | Rat, Pig, Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13976 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GABARAPL3 |
| Epitope Specificity | 1-100/117 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ATG8 family. |
| SUBUNIT | Interacts with GABRG2 and beta-tubulin (By similarity). |
| Post-translational modifications | The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Other Names | ATG8D; GBRL3_HUMAN; GABARAPL3; GABA(A) receptor-associated protein-like 3; GABA type A receptor associated protein like 3 (pseudogene); GABA(A) receptors associated protein like 3; GABA(A) receptors associated protein like 3 (pseudogene); GABA(A) receptors associated protein like 3, pseudogene |
|---|---|
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GABARAPL3 |
|---|---|
| Function | Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor |
| Tissue Location | Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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