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SLITRK4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8IW52 |
| Other Accession | Q8IW52 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 94331 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SLITRK4 |
| Epitope Specificity | 251-350/837 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the SLITRK family. Contains 12 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 1 LRRNT domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SLITRK family proteins are integral membrane proteins that have a C-terminal domain that is partially similar to TRK neurotrophin receptor proteins and two leucine-rich repeat (LRR) domains that are similar to those of SLIT proteins. SLITRK4 (SLIT and NTRK-like protein 4) is a 837 amino acid single-pass type I membrane protein that contains 18 LRR (leucine-rich) repeats and is expressed in neural tissues, specifically in the thalamus, hypothalamus, subventricular zone, CA3 region of the hippocampus and cortical plate. SLITRK4 may be upregulated in some astrocytic brain tumors such as glioblastomas, astrocytomas and primitive neuroectodermal tumors. As compared with its family member SLITRK2, SLITRK4 only weakly suppresses neurite outgrowth. A study using genome-wide transcriptional profiling suggested that the gene encoding SLITRK4, as well as the ARL5B and PLA2G7 genes, may be involved in the pathogenesis of preeclampsia. |
| Gene ID | 139065 |
|---|---|
| Other Names | 6430513G13; D930039I09Rik; SLIK4_HUMAN; SLITRK4; SLIK4_MOUSE; SLIT and NTRK like family member 4; SLIT and NTRK-like family, member 4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLITRK4 |
|---|---|
| Function | It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane |
| Tissue Location | Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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