癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NDST2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P52849 |
| Other Accession | P52849 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 100875 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NDST2 |
| Epitope Specificity | 1-100/883 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the sulfotransferase 1 family. NDST subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009] |
| Gene ID | 8509 |
|---|---|
| Other Names | HSST2; N-HSST 2; NST2; Mndns; NDST-2; ndst2; NDST2_BOVIN; CCL44; Glucosaminyl N-deacetylase/N-sulfotransferase 2 (NDST-2); 2.8.2.8; NDST2_HUMAN; N-heparan sulfate sulfotransferase 2 (N-HSST 2); NDST2_MOUSE; N-deacetylase and N-sulfotransferase 2; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NDST2 |
|---|---|
| Synonyms | HSST2 |
| Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (By similarity). Exhibits N- deacetylase activity (PubMed:16343444). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Essential for the biosynthesis of sulfated heparin in mast cells, thereby enabling proper secretory granule formation and storage of mast-cell proteases (By similarity). |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q02353}; Single-pass type II membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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