癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
T4S4 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P48230 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21396 Da |
| Antigen Region | 16-45 aa |
| Gene ID | 7104 |
|---|---|
| Other Names | Transmembrane 4 L6 family member 4, Intestine and liver tetraspan membrane protein, IL-TMP, TM4SF4, ILTMP |
| Target/Specificity | This T4S4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human T4S4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | T4S4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TM4SF4 |
|---|---|
| Synonyms | ILTMP |
| Function | Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Jejunum and liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
T4S4 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation. The use of alternate polyadenylation sites has been found for this gene.
REFERENCES
Qiao, J., et al. Reprod. Biomed. Online 17(3):425-435(2008)
Berditchevski, F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)
Wright, M.D., et al. Protein Sci. 9(8):1594-1600(2000)
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