癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Galectin 10 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q05315 |
| Other Accession | Q05315 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16453 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Galectin 10 |
| Epitope Specificity | 51-142/142 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 galectin domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Charcot-Leyden crystals are endogenous hexagonal bipyramidal crystals present in human tissues and secretions. Presence of Charcot-Leyden crystals correlates with the increased numbers of peripheral blood or tissue eosinophils that occurs with parasitic and allergic processes. Galectin-10, also referred to as Charcot-Leyden crystal (CLC) protein, singularly makes up these crystals. Galectin-10, a member of the galectin family of beta-Galactoside binding proteins that bind to S-type animal lectins, is expressed solely in eosinophilic and basophilic leukocytes. Galectin-10 may possess carbohydrate or IgE-binding activities, and it plays a functional role in the biology of inflammation. Expression of galectin-10 is transcriptionally induced by butyric acid. |
| Gene ID | 1178 |
|---|---|
| Other Names | LEG10_HUMAN; CLC; Gal-10; Charcot-Leyden crystal protein (CLC); Eosinophil lysophospholipase; Lysolecithin acylhydrolase; LGALS10; LGALS10A; Charcot-Leyden crystal galectin; Charcot-Leyden crystal protein; galectin 10; lectin, galactoside-binding, soluble, 10 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CLC |
|---|---|
| Synonyms | LGALS10, LGALS10A |
| Function | Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell |
| Tissue Location | Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97510
