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Natriuretic Peptide Receptor A Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P16066 |
| Other Accession | P16066 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 118919 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Natriuretic Peptide Receptor A |
| Epitope Specificity | 261-360/1061 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain. |
| SUBUNIT | Homodimer. |
| Post-translational modifications | Phosphorylation of the protein kinase-like domain is required for full activation by ANP. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] |
| Gene ID | 4881 |
|---|---|
| Other Names | ANPRA_HUMAN; NPR1; Atrial natriuretic peptide receptor type A (ANP-A | ANPR-A | NPR-A); Guanylate cyclase A (GC-A); 4.6.1.2; ANPRA; ANPRA_RAT; natriuretic peptide receptor 1; atrionatriuretic peptide receptor A; natriuretic peptide receptor A; guanylate cyclase A |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NPR1 (HGNC:7943) |
|---|---|
| Synonyms | ANPRA |
| Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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