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MAN1B1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UKM7 |
| Other Accession | Q9UKM7 |
| Predicted | Rat, Pig, Human, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 79580 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MAN1B1 |
| Epitope Specificity | 211-320/699 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the glycosyl hydrolase 47 family. |
| DISEASE | Mental retardation, autosomal recessive 15 (MRT15) [MIM:614202]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Note: The disease is caused by mutations affecting the gene represented in this entry. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011] |
| Gene ID | 11253 |
|---|---|
| Other Names | ERMAN1; ERManI; MANA-ER; MRT15; E430019H13Rik; Gm108; MA1B1_HUMAN; MAN1B1; ER alpha-1, 2-mannosidase; ER mannosidase 1 (ERMan1); Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1; 3.2.1.113; mannosidase, alpha, class 1B, member 1; endoplasmic reticulum alpha-mannosidase 1; alpha 1, 2-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1, 2-alpha-mannosidase 1; ER alpha 1, 2-mannosidase; Man9GlcNAc2-specific processing alpha-mannosidase; endoplasmic Reticulum Class I alpha-mannosidase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAN1B1 |
|---|---|
| Function | Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
| Tissue Location | Widely expressed. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97549
