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MPI/Mannose Phosphate Isomerase Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P34949 |
| Other Accession | P34949 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46656 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MPI/Mannose Phosphate Isomerase |
| Epitope Specificity | 61-160/423 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the mannose-6-phosphate isomerase type 1 family. |
| DISEASE | Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Gene ID | 4351 |
|---|---|
| Other Names | CDG1B; PMI; PMI1; 1110002E17Rik; Mpi-1; Mpi1; MPI_BOVIN; MPI; Phosphohexomutase; Phosphomannose isomerase (PMI); 5.3.1.8; MPI_HUMAN; MPI_MOUSE; MPI_RAT; mannose phosphate isomerase; mannose-6-phosphate isomerase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MPI (HGNC:7216) |
|---|---|
| Synonyms | PMI1 |
| Function | Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q924M7}. |
| Tissue Location | Expressed in all tissues, but more abundant in heart, brain and skeletal muscle. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97551
