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GRIK5 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q16478 |
| Other Accession | Q16478 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 109265 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GRIK5/KA2 |
| Epitope Specificity | 201-300/980 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. |
| SUBUNIT | Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of the structurally related subunits GluR-1 to -7, KA1 and KA2. KA1 (also designated EEA1) and KA2 (also designated EEA2) form heteromeric receptors with GluR subunits when coexpressed, forming ion channels with various properties. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate. |
| Gene ID | 2901 |
|---|---|
| Other Names | GRIK5_HUMAN; GRIK5; GluK5; Excitatory amino acid receptor 2 (EAA2); Glutamate receptor KA-2 (KA2); GRIK2; GRIK5_MOUSE; Glutamate receptor gamma-2 (GluR gamma-2); GRIK5_RAT; glutamate ionotropic receptor kainate type subunit 5; glutamate receptor, ionotropic, kainate 5 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GRIK5 |
|---|---|
| Synonyms | GRIK2 |
| Function | Ionotropic glutamate receptor that functions as a cation- permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1 and GRIK2 subunits (PubMed:1321949, PubMed:14511640, PubMed:8730589). Can form functional heteromeric receptors with GRIK3 (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q61626}; Multi-pass membrane protein. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q61626}; Multi-pass membrane protein. Note=Association with GRIK2 is required for its cell membrane localization and channel activity |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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