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CAPS1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9ULU8 |
| Other Accession | Q9ULU8 |
| Predicted | Rat, Pig, Human, Mouse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 152786 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CAPS1 |
| Epitope Specificity | 1231-1330/1353 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 C2 domain. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 PH domain. |
| SUBUNIT | Homodimer. Interacts with RASL10B. Interacts with the dopamine receptor DRD2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008] |
| Gene ID | 8618 |
|---|---|
| Other Names | CADPS1; CAPS; CAPS1; UNC-31; mKIAA1121; Caps2; CAPS1_HUMAN; CADPS; Calcium-dependent activator protein for secretion 1 (CAPS-1); KIAA1121; CAPS1_MOUSE; CAPS1_RAT; Calcium-dependent activator protein for secretion 1 (CAPS-1 | rCAPS); calcium dependent secretion activator; Ca++-dependent secretion activator; Ca2+ dependent secretion activator |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CADPS |
|---|---|
| Synonyms | CAPS, CAPS1, KIAA1121 |
| Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2- binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). |
| Cellular Location | Synapse {ECO:0000250|UniProtKB:Q62717}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:Q62717}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62717}. Note=Membrane-associated to vesicles Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2 {ECO:0000250|UniProtKB:Q62717} |
| Tissue Location | Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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