癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EMR4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q86SQ3 |
| Other Accession | Q86SQ3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50903 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human EMR4 |
| Epitope Specificity | 331-440/457 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Contains 2 EGF-like domains.Contains 1 GPS domain. |
| SUBUNIT | Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity). |
| Post-translational modifications | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008] |
| Other Names | EMR4; EMR4P; FIRE; GPR127; PGR16; AGRE4_HUMAN; ADGRE4P; EGF-like module receptor 4; EGF-like module-containing mucin-like hormone receptor-like 4; G-protein coupled receptor 127; G-protein coupled receptor PGR16; adhesion G protein-coupled receptor E4, pseudogene; G protein-coupled receptor 127; egf-like module containing, mucin-like, hormone receptor-like 4; egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene |
|---|---|
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADGRE4P (HGNC:19240) |
|---|---|
| Function | May mediate the cellular interaction between myeloid cells and B-cells. |
| Cellular Location | [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q91ZE5}; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP97571
