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ZNF238 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q99592 |
| Other Accession | Q99592 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58354 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZNF238 |
| Epitope Specificity | 351-450/522 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| Gene ID | 10472 |
|---|---|
| Other Names | C1DELq42q44; C1DELq43q44; C2H2-171; DEL1Q42Q44; DEL1Q43Q44; MRD22; RP58; TAZ-1; ZNF238; Zfp238; Znf238.; zfp-238; ZBT18_HUMAN; ZBTB18; 58 kDa repressor protein; Transcriptional repressor RP58; Translin-associated zinc finger protein 1 (TAZ-1); Zinc finger protein 238; Zinc finger protein C2H2-171; TAZ1; ZBT18_MOUSE; Zinc finger protein 238 (Zfp-238); ZBT18_RAT; 58 kDa repressor protein (rRP58); zinc finger and BTB domain containing 18 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZBTB18 |
|---|---|
| Synonyms | RP58, TAZ1, ZNF238 |
| Function | Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. |
| Cellular Location | Nucleus. Note=Associates with condensed chromatin |
| Tissue Location | Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP97578
