癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HECTD2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q5U5R9 |
| Other Accession | Q5U5R9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 88122 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HECTD2 |
| Epitope Specificity | 701-776/776 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | HECT (Homologous to the E6-AP Carboxyl Terminus) proteins are a large group of E3 ubiquitin-ligases that play a role in the specificity and selectivity of ubiquitylation. The human genome encodes at least 20 different HECT domain proteins, which are grouped into two classes based on their E2 specificity. HECT enzymes also regulate the trafficking of many receptors, transporters, viral proteins and channels. Since HECT proteins are involved in the degradation of vital tumor suppressor molecules, it is theorized that some may contribute to tumorigenesis. HECTD2 (HECT domain-containing protein 2) is a 776 amino acid E3 ubiquitin-ligase that characteristically accepts ubiquitin from an E2 ubquitin-conjugating enzyme and directly transfers the ubiquitin to targeted substrates. Recently, HECTD2 haplotypes have been linked to the susceptibility of acquiring human prion diseases such as Creutzfeldt-Jakob Disease and kuru, which present after a long, clinically silent incubation period that seems to be determined by factors such as genetic background. |
| Gene ID | 143279 |
|---|---|
| Other Names | 4921524L07; A630025O09Rik; CR201_G0037942; HECD2_HUMAN; HECTD2; HECT domain-containing protein 2; HECT-type E3 ubiquitin transferase HECTD2; 2.3.2.26; HECD2_MOUSE; HECD2_PONAB; HECT domain E3 ubiquitin protein ligase 2; HECT domain containing E3 ubiquitin protein ligase 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HECTD2 {ECO:0000303|PubMed:28584101, ECO:0000312|HGNC:HGNC:26736} |
|---|---|
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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