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GABRA6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q16445 |
| Other Accession | Q16445 |
| Predicted | Rat, Pig, Human, Mouse, Rabbit, Dog, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51024 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GABRA6/GABA A Receptor alpha 6 |
| Epitope Specificity | 85-180/453 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily. |
| SUBUNIT | Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008] |
| Gene ID | 2559 |
|---|---|
| Other Names | GABA-ARalpha6; Gabra-6; alpha6; GBRA6_HUMAN; GABRA6; GABA(A) receptor subunit alpha-6 (GABAAR subunit alpha-6); GBRA6_MOUSE; GBRA6_RAT; gamma-aminobutyric acid type A receptor subunit alpha6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; GABA(A) receptor, alpha 6 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GABRA6 (HGNC:4080) |
|---|---|
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:8632757). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:8632757). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses (By similarity). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P30191}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P30191}; Multi-pass membrane protein |
| Tissue Location | Expressed in brain, in cerebellar granule cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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