癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FBXL20 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96IG2 |
| Other Accession | Q96IG2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48423 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FBXL20 |
| Epitope Specificity | 101-200/436 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 F-box domain. Contains 13 LRR (leucine-rich) repeats. |
| SUBUNIT | Interacts with SKP1 and CUL1. |
| DISEASE | Contains 1 F-box domain. Contains 13 LRR (leucine-rich) repeats. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
| Gene ID | 84961 |
|---|---|
| Other Names | Fbl2; Fbl20; 2610511F20Rik; 4632423N09Rik; Scr; mKIAA4147; Fbxl2; FXL20_HUMAN; FBXL20; F-box and leucine-rich repeat protein 20; F-box/LRR-repeat protein 2-like; FXL20_MOUSE; FXL20_RAT; F-box and leucine rich repeat protein 20 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FBXL20 |
|---|---|
| Synonyms | FBL2 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). |
| Cellular Location | Cytoplasm. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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