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Glutaredoxin 5 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q86SX6 |
| Other Accession | Q86SX6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16628 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Glutaredoxin 5 |
| Epitope Specificity | 51-157/157 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the glutaredoxin family. Monothiol subfamily. Contains 1 glutaredoxin domain. |
| SUBUNIT | Homodimer. |
| DISEASE | Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA) [MIM:205950]. A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010] |
| Gene ID | 51218 |
|---|---|
| Other Names | C14orf87; FLB4739; GRX5; PR01238; PRO1238; PRSA; SIDBA3; SPAHGC; RGD1308383; GLRX5_HUMAN; GLRX5; Monothiol glutaredoxin-5; GLRX5_MOUSE; glutaredoxin 5; chromosome 14 open reading frame 87; glutaredoxin 5 homolog (S. cerevisiae) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GLRX5 |
|---|---|
| Synonyms | C14orf87 |
| Function | Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron- sulfur protein ACO1 (PubMed:20364084). |
| Cellular Location | Mitochondrion matrix |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97595
