癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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SNX27 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q96L92 |
| Other Accession | Q96L92 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61265 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SNX27 |
| Epitope Specificity | 351-450/541 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the sorting nexin family. Contains 1 PDZ (DHR) domain. Contains 1 PX (phox homology) domain. Contains 1 Ras-associating domain. |
| SUBUNIT | Interacts with PSCDBP. Isoforms 1 and 2 directly interact with DGKZ. Isoforms 1 and 2 interact with HT4R isoform 5-HTA(A). Interacts with MCC. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SNX27 is involved in endocytic trafficking. In T lymphocytes it participates in the endocytic recycling pathway. SNX27 recruits PSCDBP and HT4R to early endosomes. |
| Gene ID | 81609 |
|---|---|
| Other Names | MRT1; MY014; SNX27_HUMAN; SNX27; KIAA0488; sorting nexin 27; sorting nexin family member 27 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SNX27 |
|---|---|
| Synonyms | KIAA0488 |
| Function | Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. |
| Cellular Location | Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T- cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products |
| Tissue Location | Widely expressed. Expressed in cells of hematopoietic origin (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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