癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LEPRE1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q32P28 |
| Other Accession | Q32P28 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 83394 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LEPRE1 |
| Epitope Specificity | 351-450/736 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the leprecan family. Contains 1 Fe2OG dioxygenase domain. Contains 4 TPR repeats. |
| Post-translational modifications | O-glycosylated; chondroitin sulfate. |
| DISEASE | Defects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8) [MIM:610915]. A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011] |
| Gene ID | 64175 |
|---|---|
| Other Names | GROS1; LEPRE1; OI8; 2410024C15Rik; P3H1_HUMAN; P3H1; Growth suppressor 1; Leucine- and proline-enriched proteoglycan 1 (Leprecan-1); 1.14.11.7; P3H1_MOUSE; P3H1_RAT; prolyl 3-hydroxylase 1; leucine proline-enriched proteoglycan (leprecan) 1; procollagen-proline 3-dioxygenase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | P3H1 (HGNC:19316) |
|---|---|
| Function | Has prolyl 3-hydroxylase activity and catalyzes the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen trimers (PubMed:39245686). May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. |
| Cellular Location | [Isoform 1]: Endoplasmic reticulum |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97626
