癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LILRA3/CD85e Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8N6C8 |
| Other Accession | Q8N6C8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47472 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LILRA3/CD85e |
| Epitope Specificity | 311-400/439 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 4 Ig-like C2-type (immunoglobulin-like) domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014] Annotation informationAnnotation category: only annotated on alternate loci in reference assembly |
| Gene ID | 11026 |
|---|---|
| Other Names | CD85E; HM31; HM43; ILT-6; ILT6; LIR-4; LIR4; LIRA3_HUMAN; LILRA3; CD85 antigen-like family member E; Immunoglobulin-like transcript 6 (ILT-6); Leukocyte immunoglobulin-like receptor 4 (LIR-4); Monocyte inhibitory receptor HM43/HM31; leukocyte immunoglobulin like receptor A3; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3; leucocyte Ig-like receptor A3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LILRA3 |
|---|---|
| Synonyms | ILT6, LIR4 |
| Function | Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF production by monocytes. |
| Cellular Location | Secreted. |
| Tissue Location | Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97644
