癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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TCF12 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q99081 |
| Other Accession | Q99081 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72965 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TCF12 |
| Epitope Specificity | 51-150/682 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 bHLH (basic helix-loop-helix) domain. |
| SUBUNIT | Binds specifically to oligomers of E-box motifs. May play important roles during development of the nervous system as well as in other organ systems. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression. |
| Gene ID | 6938 |
|---|---|
| Other Names | CRS3; HEB; HH26; HTF4; HsT17266; TCF-12; bHLHb20; p64; HTF4_HUMAN; TCF12; Class B basic helix-loop-helix protein 20 (bHLHb20); DNA-binding protein HTF4; E-box-binding protein; Transcription factor HTF-4; transcription factor 12; helix-loop-helix transcription factor 4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TCF12 |
|---|---|
| Synonyms | BHLHB20, HEB, HTF4 |
| Function | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97661
