癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Visual Arrestin Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P10523 |
| Other Accession | P10523 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45120 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Visual Arrestin |
| Epitope Specificity | 141-240/405 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the arrestin family. |
| DISEASE | Defects in SAG are the cause of congenital stationary night blindness Oguchi type 1 (CSNBO1) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. Defects in SAG are the cause of retinitis pigmentosa type 47 (RP47) [MIM:613758]. RP47 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Members of the Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors, and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Visual Arrestin, also known as Arrestin, retinal S-antigen or S-Arrestin, is a major soluble photoreceptor protein that regulates light-dependent signal transduction through G protein-coupled receptor (rhodopsin) activation. Visual Arrestin is expressed in retinal photoreceptor cells and the pineal gland. Visual Arrestin is the major pathogenic autoantigen in inflammatory eye disease, such as uveoretinitis and Oguchi disease, a rare autosomal recessive form of night blindness. |
| Gene ID | 6295 |
|---|---|
| Other Names | ARRS_BOVIN; SAG; 48 kDa protein; Retinal S-antigen (S-AG); Rod photoreceptor arrestin; ARRS_HUMAN; ARRS_MOUSE; ARRS_RAT; S-antigen visual arrestin; S-antigen; retina and pineal gland (arrestin); arrestin 1; rod arrestin |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SAG |
|---|---|
| Function | Involved in the regulation of phototransduction, playing a key role in signal termination after rhodopsin (RHO) has been activated by light in rod photoreceptors. Binds to photoactivated and phosphorylated RHO, preventing its interaction with transducin (GNAT1) and terminating transducin-mediated opsin signaling (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049). |
| Cellular Location | Photoreceptor inner segment {ECO:0000250|UniProtKB:P20443}. Cell projection, cilium, photoreceptor outer segment. Membrane {ECO:0000250|UniProtKB:P20443}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20443}. Note=In dark-adapted retina, it is predominatly localized to the outer nuclear layer and photoreceptor inner segments (By similarity). Localized to photoreceptor outer segments in light-exposed retina. During light exposure it first accumulates in the proximal region of photoreceptor outer segments, and moves toward the distal tip of the outer segment as light exposure is prolonged (By similarity). {ECO:0000250|UniProtKB:P20443} |
| Tissue Location | Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97700
