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IL21R Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9HBE5 |
| Other Accession | Q9HBE5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59130 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-21R |
| Epitope Specificity | 441-538/538 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. |
| SUBUNIT | Heterodimer with the common gamma subunit. Associates with JAK1. |
| Post-translational modifications | C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] |
| Gene ID | 50615 |
|---|---|
| Other Names | CD360; IMD56; NILR; IL21R_HUMAN; IL21R; IL-21 receptor; IL-21R; Novel interleukin receptor; IL21R_MOUSE; Lymphocyte receptor beta (LR-beta); Novel cytokine receptor 8 (NR8); Q5EBB1_RAT; interleukin 21 receptor |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IL21R |
|---|---|
| Synonyms | NILR |
| Function | This is a receptor for interleukin-21. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97725
