癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SUPV3L1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q8IYB8 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87991 Da |
| Antigen Region | 93-121 aa |
| Gene ID | 6832 |
|---|---|
| Other Names | ATP-dependent RNA helicase SUPV3L1, mitochondrial, Suppressor of var1 3-like protein 1, SUV3-like protein 1, SUPV3L1, SUV3 |
| Target/Specificity | This SUPV3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-121 amino acids from the N-terminal region of human SUPV3L1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SUPV3L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUPV3L1 |
|---|---|
| Synonyms | SUV3 |
| Function | Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. |
| Cellular Location | Nucleus. Mitochondrion matrix Mitochondrion matrix, mitochondrion nucleoid |
| Tissue Location | Broadly expressed.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SUV3L1 is an ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction. It may protect cells from apoptosis.
REFERENCES
Szczesny, R.J., et al. Nucleic Acids Res. 38(1):279-298(2010)
Wang, D.D., et al. J. Biol. Chem. 284(31):20812-20821(2009)
Khidr, L., et al. J. Biol. Chem. 283(40):27064-27073(2008)
Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)
Pereira, M., et al. Mech. Ageing Dev. 128 (11-12), 609-617 (2007)
Shu, Z., et al. Biochemistry 43(16):4781-4790(2004)
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