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PNPO Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NVS9 |
| Other Accession | Q9NVS9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29988 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PNPO |
| Epitope Specificity | 41-140/261 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the pyridoxamine 5'-phosphate oxidase family. |
| SUBUNIT | Homodimer. |
| DISEASE | Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). |
| Gene ID | 55163 |
|---|---|
| Other Names | HEL-S-302; PDXPO; PNPO_HUMAN; PNPO; Pyridoxamine-phosphate oxidase; 1.4.3.5; PNPO_MOUSE; PNPO_RAT; pyridoxamine 5'-phosphate oxidase; pyridoxine 5'-phosphate oxidase; pyridoxal 5'-phosphate synthase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PNPO |
|---|---|
| Function | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). |
| Tissue Location | Ubiquitous. Expressed in liver, brain, lung, prostate and stomach (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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